Article

Conserved protein sequence-structure signatures identify antibiotic resistance genes from the human microbiome

2025-10-02

Abstract excerpt

Bacteria exhibiting antimicrobial resistance (AMR) is a problem that has grown to become a significant public health challenge worldwide. Antibiotic resistance genes (ARGs), determinants of AMR, mostly emerge from non-clinical settings. Identifying previously undetected ARGs in the human microbiome which confer resistance to clinical concentrations of antibiotics is a crucial component of addressing AMR, yet can b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7db598e2-c5ac-57fb-8b0c-c020daa16903
DOI: 10.1101/2025.10.01.679039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Conserved protein sequence-structure signatures identify antibiotic resistance genes from the human microbiomeDOI 10.1101/2025.10.01.679039Read

Resistance genes are distinct in protein-protein interaction networks according to drug class and gene mobilitySemantic proximity Read

Structure-guided metagenome mining to tap microbial functional diversity.Semantic proximity Read

An omics-based framework for assessing the health risk of antimicrobial resistance genesSemantic proximity Read

Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-LactamasesSemantic proximity Read

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogensSemantic proximity Read

BacARscan: A Comprehensive and Interactive Web-Resource to Discern Antibiotic Resistance Gene Diversity in –Omics DatasetsSemantic proximity Read

Sequencing methods to study the microbiome with antibiotic resistance genes in patients with pulmonary infectionsSemantic proximity Read

Blanket antimicrobial resistance gene database with structural information, BOARDS, provides insights on historical landscape of resistance prevalence and effects of mutations in enzyme structure.Semantic proximity Read

Exploring uncatalogued genetic variation in antimicrobial resistance gene families in Escherichia coli: an observational analysis.Semantic proximity Read

ARMOR (Antibiotic Resistance Modelling through Omics and Resistance-gene analysis)Semantic proximity Read

VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learningSemantic proximity Read

A machine learning framework to predict antibiotic resistance traits and yet unknown genes underlying resistance to specific antibiotics in bacterial strains.Semantic proximity Read