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Article

EPAS1 is associated with human muscle fiber composition and endurance phenotypes.

Physiological reports - 1 May 2026

Dautova Albina Z, Valeeva Elena V, Semenova Ekaterina A, Mavliev Fanis A, Zverev Alexey A, Nazarenko Andrey S, John George, Zhelankin Andrey V, Larin Andrey K, Kulemin Nikolay A, Sultanov Rinat I, Generozov Edward V, Ahmetov Ildus I

Abstract excerpt

A recent study reported that endothelial PAS domain protein 1 (EPAS1; hypoxia-inducible factor 2α) acts downstream of PGC-1α to regulate the slow-twitch muscle fiber program in mice, yet its role in human physiology and exercise adaptation remains unclear. The aim of this study was threefold: (1) to investigate EPAS1 gene expression in human skeletal muscle and its association with muscle fiber composition and...

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Share to Muscle Fibers, Skeletal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle Fibers, Slow-Twitch

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Source

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Identifiers

PMID: 42157436
DOI: 10.14814/phy2.70928
PMCID: PMC13423621

Genes

EPAS1
ANGPT2
CKM
CPT1B
EPOR
FNDC5
HIF1A
KDR
MYBPC3
NFATC4
NOS3
PGC
PPARA
PPARD
PPARGC1A
UCP2
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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