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Article

Expression and Variations in EPAS1 Associated with Oxygen Metabolism in Sheep.

Genes - 15 Oct 2022

Xi Qiming, Zhao Fangfang, Hu Jiang, Wang Jiqing, Liu Xiu, Dang Pengju, Luo Yuzhu, Li Shaobin

Abstract excerpt

Endothelial PAS domain protein 1 gene (EPAS1) is a member of the HIF gene family. This gene encodes a transcription factor subunit that is involved in the induction of oxygen-regulated genes. Several studies have demonstrated that a mutation in EPAS1 could affect oxygen sensing, polycythemia, and hemoglobin level. However, whether EPAS1 mutation affects sheep oxygen metabolism is still unknown. Therefore, we...

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PMID: 36292756
DOI: 10.3390/genes13101871
PMCID: PMC9602176

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