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Article

Association of genomic driver mutation, histologic subtype, and mTORC1 biomarker expression in mTOR pathway-altered renal tumors.

Human pathology - 1 Sept 2026

Bhardwaj Swati, Amaral Adrianna, Dairo Oluwademilade, Akbari Amir, Pivovarcikova Kristyna, Williamson Sean R, Antic Tatjana, Argani Pedram, Asrani Kaushal, Lotan Tamara L

Abstract excerpt

A widening spectrum of renal tumors is driven by alterations in mTOR pathway genes. We examined the relationship between the specific underlying genomic driver mutation, mTOR signaling activation and tumor histologic subtype among mTOR pathway-altered tumors. mTOR pathway activation was assessed by quantifying expression of GPNMB in 16 cases of eosinophilic vacuolated tumor (EVT), 13 cases of low grade oncocytic...

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Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mechanistic Target of Rapamycin Complex 1

Share to TOR Serine-Threonine Kinases

Share to Tuberous Sclerosis Complex 1 Protein

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Source

Identifiers

PMID: 42155824
DOI: 10.1016/j.humpath.2026.106154

Genes

GPNMB
MTOR
TSC1
PIK3CA
NF1
PTEN
RHEB
RICTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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