MTOR-mutated eosinophilic renal cell carcinomas with loss of chromosome 1 and high metastatic potential: further expanding the spectrum of TSC/mTOR pathway mutated renal tumors.

doi:10.1007/s00428-025-04363-4

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Article

MTOR-mutated eosinophilic renal cell carcinomas with loss of chromosome 1 and high metastatic potential: further expanding the spectrum of TSC/mTOR pathway mutated renal tumors.

Virchows Archiv : an international journal of pathology - 1 Sept 2026

Kwon Jung Woo, Tjota Melissa Y, Antic Tatjana

Abstract excerpt

TSC/mTOR pathway alteration is recurrent in numerous renal tumor types, such as eosinophilic vacuolated tumor (EVT), low-grade oncocytic tumor of the kidney (LOT), and eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC). Recently, additional renal tumor types with recurrent TSC/mTOR pathway mutation, such as xanthomatous giant cell RCC and RCC with leiomyomatous stroma, have also been described,...

Read the complete abstract on PubMed

Topics

Humans
TOR Serine-Threonine Kinases
Kidney Neoplasms
Carcinoma, Renal Cell
Mutation
Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Biomarkers, Tumor

Middle Aged

Signal Transduction

Tuberous Sclerosis Complex 1 Protein

Immunohistochemistry

Source

Open in PubMed Open full text

Identifiers

PMID: 41299159
DOI: 10.1007/s00428-025-04363-4
PMCID: PMC13582412

Genes

MTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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