Article
Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2022
Kapur Payal, Gao Ming, Zhong Hua, Chintalapati Suneetha, Mitui Midori, Barnes Spencer D, Zhou Qinbo, Miyata Jeffrey, Carrillo Deyssy, Malladi Venkat S, Rakheja Dinesh, Pedrosa Ivan, Xu Lin, Kinch Lisa, Brugarolas James
Abstract excerpt
Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly understood pathogenesis. Using next-generation sequencing (NGS) and complementary approaches, we provide insight into its biology. We describe 22 LOT corresponding to 7 patients presenting with a median age of 75 years (range 63-86 years) and male to female ratio 2:5. All 22 tumors demonstrated prototypical microscopic...
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