Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases.

doi:10.1038/s41379-021-00923-6

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Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2022

Farcaş Mihaela, Gatalica Zoran, Trpkov Kiril, Swensen Jeffrey, Zhou Ming, Alaghehbandan Reza, Williamson Sean R, Magi-Galluzzi Cristina, Gill Anthony J, Tretiakova Maria, Lopez Jose I, Montiel Delia Perez, Sperga Maris, Comperat Eva, Brimo Fadi, Yilmaz Asli, Siadat Farshid, Sangoi Ankur, Gao Yuan, Ptákova Nikola, Kuthi Levente, Pivovarcikova Kristyna, Rogala Joanna, Agaimy Abbas, Hartmann Arndt, Fraune Cristoph, Rychly Boris, Hurnik Pavel, Durcansky Dušan, Bonert Michael, Gakis Georgios, Michal Michal, Hora Milan, Hes Ondrej

Abstract excerpt

A distinct renal tumor has recently been described as "high-grade oncocytic renal tumor" and "sporadic renal cell carcinoma with eosinophilic and vacuolated cytoplasm". The Genitourinary Pathology Society (GUPS) consensus proposed a unifying name "eosinophilic vacuolated tumor" (EVT) for this emerging entity. In this multi-institutional study, we evaluated 19 EVTs, particularly their molecular features and...

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PMID: 34521993
DOI: 10.1038/s41379-021-00923-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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