Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome.

doi:10.1038/s41379-020-0607-z

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Article

Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020

Roldan-Romero Juan María, Santos María, Lanillos Javier, Caleiras Eduardo, Anguera Georgia, Maroto Pablo, García-Donas Jesús, de Velasco Guillermo, Martinez-Montes Ángel Mario, Calsina Bruna, Monteagudo María, Letón Rocío, Leandro-García Luis Javier, Montero-Conde Cristina, Cascón Alberto, Robledo Mercedes, Rodriguez-Antona Cristina

Abstract excerpt

Chromophobe renal cell carcinoma (chRCC) is a histologically and molecularly distinct class of rare renal tumor. TCGA studies revealed low mutational burden, with only TP53 and PTEN recurrently mutated, and discovered alterations in TERT promoter and in the electron transport chain Complex I genes. However, knowledge on drug targetable genes is limited and treatments at metastatic stage do not follow a molecular...

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PMID: 32616874
DOI: 10.1038/s41379-020-0607-z

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