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Article

Molecular and microenvironmental landscapes of human papillomavirus-independent invasive squamous cell carcinoma of the vulva.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Feb 2025

Moufarrij Sara, Filippova Olga, Da Cruz Paula Arnaud, Heredia Juan Blanco, Green Hunter, Broach Vance, Leitao Mario M, O'Cearbhaill Roisin E, Abu-Rustum Nadeem R, Park Kay J, Weigelt Britta, Zamarin Dmitriy

Abstract excerpt

OBJECTIVE: Human papillomavirus (HPV)-independent vulvar squamous cell carcinoma has a worse prognosis compared to its HPV-associated counterpart. We sought to characterize the mutational landscape and the tumor microenvironment of HPV-independent vulvar cancer. METHODS: Primary, untreated vulvar cancers with known HPV-independent vulvar cancer or without definitive HPV association between 2006 and 2016 were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39971436
DOI: 10.1016/j.ijgc.2024.100051
PMCID: PMC12872033

Genes

CD68
CDKN2A
CXCL8
FAT1
NOTCH1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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