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Article

Why recombination hotspots?

PLoS genetics - 1 May 2026

Joseph Julien, Brazier Thomas, Raynaud Marie, Glémin Sylvain, Baudat Frédéric, de Massy Bernard, Lartillot Nicolas, Duret Laurent

Abstract excerpt

Meiotic recombination is the process by which DNA is exchanged between parental chromosomes during the production of gametes in eukaryotes. This phenomenon has important implications for fertility, genetic diversity and genome stability. Intriguingly, not all regions of the genome are equally susceptible to recombine during meiosis. Instead, in many eukaryotes, recombination events are concentrated in short...

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PMID: 42154786
DOI: 10.1371/journal.pgen.1012152
PMCID: PMC13186367

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