Sequence-Specific Primer Polymerase Chain Reaction Genotyping of the Human TLR9 Promoter Polymorphism rs187084 (-1486T>C).

doi:10.1002/cpz1.70390

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Article

Sequence-Specific Primer Polymerase Chain Reaction Genotyping of the Human TLR9 Promoter Polymorphism rs187084 (-1486T>C).

Current protocols - 1 May 2026

Castellani Guilherme, Massi Fernanda Pelisson, Yamanaka Aléia Harumi Uchibaba, Neto Quirino Alves de Lima, Pinto Larissa Danielle Bahls

Abstract excerpt

This article describes a validated and optimized sequence-specific primer polymerase chain reaction (PCR-SSP) protocol for genotyping the human TLR9 promoter polymorphism rs187084 (-1486T>C). Promoter single nucleotide polymorphisms (SNPs) may influence transcriptional regulation and immune signaling. The rs187084 variant has been associated with altered TLR9 expression and susceptibility to infectious,...

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