Article
The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation.
PloS one - 1 Jan 2011
Carvalho Agostinho, Osório Nuno S, Saraiva Margarida, Cunha Cristina, Almeida Agostinho J, Teixeira-Coelho Maria, Ludovico Paula, Pedrosa Jorge, Pitzurra Lucia, Aversa Franco, Romani Luigina, Castro António G, Rodrigues Fernando
Abstract excerpt
In humans, allelic variants in Toll-like receptors (TLRs) associate with several pathologies. However, the underlying cellular and molecular mechanisms of this association remain largely unknown. Analysis of the human TLR9 promoter revealed that the C allele of the rs5743836 polymorphism generates several regulatory sites, including an IL-6-responding element. Here, we show that, in mononuclear cells carrying the...
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