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Article

Targeting both rs12979860 and rs8099917 polymorphisms with a single-tube high-resolution melting assay for IL28b genotyping.

Journal of clinical microbiology - 1 Oct 2012

Poon Kok Siong, Ho Sherry Sze Yee, Tang Julian Wei-Tze, Chua Cui Wen, Chiu Lily, Koay Evelyn Siew-Chuan

Abstract excerpt

A rapid, duplex, high-resolution melting interleukin-28B gene (IL28B) genotyping assay, targeting both rs12979860 and rs8099917 polymorphisms, was developed and validated using 30 DNA samples from healthy volunteers. A linkage study on 300 healthy Singaporeans showed variable haplotypes. When the assay was applied to plasma DNA from 50 hepatitis C virus genotype-1 (HCV-1)-infected patients, five compound...

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Identifiers

PMID: 22814458
DOI: 10.1128/JCM.01718-12
PMCID: PMC3457426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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