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Article

Rapid Cas13a-based penA genotyping for cefixime susceptibility in Neisseria gonorrhoeae.

mSphere - 30 Jun 2026

Nguyen Thi Hai Yen, Garg Sakshi, Adams Gordon, Mantena Sreekar, Gopal Nisha, Suk Ho-Jun, D Klausner Jeffrey, Sabeti Pardis C, Lemieux Jacob E, Allan-Blitz Lao-Tzu

Abstract excerpt

Antimicrobial resistance in Neisseria gonorrhoeae is an urgent public health threat. Resistance-guided therapy can assure appropriate treatment and reintroduce alternative therapeutic options by identifying genetic predictors of resistance. Mosaicism at codons 375-377 of the penA gene is associated with cefixime resistance. Rapid, field-deployable assays for predicting cefixime susceptibility are lacking. We used...

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Identifiers

PMID: 42153664
DOI: 10.1128/msphere.00182-26
PMCID: PMC13317185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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