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Article

Genetically predicted serum Pimelylcarnitine mediates the association between CD39+ secreting Treg cells and intervertebral disc degeneration.

Medicine - 15 May 2026

Li Na, Shen Cimin, Huang Zhenv, Shao Zhuoyi, Wu Jietao, Hua Danyun, Wang Lu

Abstract excerpt

Investigating the causal relationship between CD39+ secreting Treg cells and intervertebral disc degeneration (IVDD) and identifying and quantifying the role of pimelylcarnitine (C7-DC) as a potential mediator. Using summary-level data from a genome-wide association study, a two-sample Mendelian randomization (MR) analysis of genetically predicted CD39+ secreting Treg (N = 3045) and IVDD (41,669 cases, 294,770...

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Share to Antigens, CD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42152416
DOI: 10.1097/MD.0000000000048540
PMCID: PMC13183168

Genes

C7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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