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Article

The bidirectional genetic causality between immunocyte phenotypes and dilated cardiomyopathy: A bidirectional Mendelian randomization study.

Medicine - 17 Jul 2026

Feng Wenshuai, Chang Xindi, Li Qiaozhi, Dong Zhengwei, Jin Ge, Huang Jinyu, Fan Genhao, Xing Zuoying, Wang Yongxia

Abstract excerpt

The association between immunocyte phenotypes and dilated cardiomyopathy (DCM) has been explored, however the exact pathogenesis of the relationship between immune cells and DCM is unclear. This bidirectional two-sample Mendelian randomization (MR) research aims to further validate the causal link between 731 immunocyte phenotypes and DCM. Summary statistics from a genome-wide association study data of...

Topics

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Cardiomyopathy, Dilated
CD28 Antigens
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

T-Lymphocytes, Regulatory

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Open in PubMed Open full text

Identifiers

PMID: 42470070
DOI: 10.1097/MD.0000000000049691
PMCID: PMC13384680

Genes

CD28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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