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Article

Sex-aware causal inference assessment of the immune system in complex neurodegenerative diseases.

Brain : a journal of neurology - 3 Aug 2026

Lona-Durazo Frida, Byrne Ross P, Pilon Marc-Olivier, Greicius Michael D, Dubé Marie-Pierre, Belloy Michael E, McLaughlin Russell L, Gagliano Taliun Sarah A

Abstract excerpt

Sex differences, in terms of prevalence, symptoms and disease progression, are established in the aetiology of complex neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease, but the underlying biology driving these differences remains poorly understood. There is emerging evidence from genetic and functional analyses affirming the role of the immune system...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41437896
DOI: 10.1093/brain/awaf474
PMCID: PMC13431771

Genes

ADGRE2
CD2AP
CD33
COLEC11
CSF3
FCGR2A
GPNMB
GRN
MAMDC2
OMG
PCDH17
SERPINF2
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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