Frontotemporal Dementia due to the Novel GRN Arg161GlyfsX36 Mutation.

Abstract excerpt

Progranulin is a multifunctional growth factor mainly expressed in neurons and microglia. Loss-of-function mutations in the Granulin (GRN) gene are causative of frontotemporal dementia with TAR DNA-binding protein-43 inclusions. We reported the case of a 51-year-old male patient affected by sporadic agrammatic variant of primary progressive aphasia, in whom we identified a novel heterozygous deletion in the exon...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aphasia, Primary Progressive
• Share to Brain