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Article

Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.

Acta neuropathologica communications - 27 Jan 2023

Cabron Anne-Sophie, Borgmeyer Uwe, Richter Julia, Peisker Helga, Gutbrod Katharina, Dörmann Peter, Capell Anja, Damme Markus

Abstract excerpt

Genetic variants in TMEM106B are a common risk factor for frontotemporal lobar degeneration and the most important modifier of disease risk in patients with progranulin (GRN) mutations (FTLD-GRN). TMEM106B is encoding a lysosomal transmembrane protein of unknown molecular function. How it mediates its disease-modifying function remains enigmatic. Several TMEM106B single nucleotide polymorphisms (SNPs) are...

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Identifiers

PMID: 36707901
DOI: 10.1186/s40478-023-01510-3
PMCID: PMC9881268

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Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.PMID 36707901Read ↗

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.Semantic proximity Read ↗

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.Semantic proximity Read ↗

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read ↗

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicitySemantic proximity Read ↗

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.Semantic proximity Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementiaSemantic proximity Read ↗

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Semantic proximity Read ↗

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.Semantic proximity Read ↗

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.Semantic proximity Read ↗

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Semantic proximity Read ↗

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Semantic proximity Read ↗

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