Total saponins of Trillium tschonoskii Maxim. mitigate locomotor deficits associated with cerebral ischemia by facilitating microglial phenotype switching through the Jagged1/Notch1/Hes5 signaling pathway.

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Trillium tschonoskii Maxim. (TTM) is a traditional Chinese medicinal herb historically employed to enhance functional recovery in patients with cerebrovascular disorders, particularly during post-stroke rehabilitation. AIM OF THE STUDY: Despite its documented therapeutic benefits, the underlying molecular mechanisms by which TTM mitigated ischemic injury remain poorly understood....

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