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Article

Implications of TLR4 Polymorphisms for Precision Therapeutics in Gram-negative Infections: An Ethnogeographic-Stratified Meta-Analysis.

Clinical therapeutics - 1 Jul 2026

Ospina Beatriz Giraldo, Castrillón Iván Alberto Lopera, Castaño Sandra Catalina Garzón, Tobón Daniel Duque, Muñoz Diego Fernando López

Abstract excerpt

PURPOSE: To quantify definitively the impact of loss-of-function variants of Toll-like receptor 4 (TLR4) (Asp299Gly, rs4986790 and Thr399Ile, rs4986791) on the susceptibility to, and mortality from, Gram-negative bacterial infections, and to evaluate how these associations are modulated by ethnogeographic factors. METHODS: This systematic review and meta-analysis was prospectively registered (PROSPERO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42140794
DOI: 10.1016/j.clinthera.2026.04.008

Genes

TLR4

Variants

rs4986790
rs4986790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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