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Article

Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.

The Journal of biological chemistry - 22 Jul 2011

Leung Grace P, Lee Linda, Schmidt Thorsten I, Shirahige Katsuhiko, Kobor Michael S

Abstract excerpt

Genome integrity is maintained by a network of DNA damage response pathways, including checkpoints and DNA repair processes. In Saccharomyces cerevisiae, the BRCT domain-containing protein Rtt107/Esc4 is required for the restart of DNA replication after successful repair of DNA damage and for cellular resistance to DNA-damaging agents. In addition to its well characterized interaction with the endonuclease Slx4,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21642432
DOI: 10.1074/jbc.M111.235200
PMCID: PMC3138301

Genes

SMC5

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.PMID 21642432Read ↗

Rtt107 BRCT domains act as a targeting module in the DNA damage response.Semantic proximity Read ↗

Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.Semantic proximity Read ↗

Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase.Semantic proximity Read ↗

Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Semantic proximity Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

Rtt107 cooperates with Rad55 to limit specific types of genome instability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.Semantic proximity Read ↗

Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.Semantic proximity Read ↗

The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster.Semantic proximity Read ↗

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