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Article

Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity.

PloS one - 1 Jan 2026

Liang Xiaotong, Pan Shun, Ji Jiting, Deng Yuying, Chen Miao, Huang Ziwei, Deng Jiaru, Chen Min, Xiong Tiantian, Liang Jianping, Liu Li

Abstract excerpt

OBJECTIVE: This study aimed to investigate the associations between functional genetic variants in leptin-melanocortin pathway and risk of childhood obesity, as well as exploring gene-lifestyle interactions on obesity risk. METHODS: A frequency-matched case-control study included 1123 children and adolescents with obesity and 1231 controls from Guangzhou, China. Twelve potentially functional genetic variants were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42139370
DOI: 10.1371/journal.pone.0348694
PMCID: PMC13178977

Genes

LEPR
MC4R
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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