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Article

Mendelian randomization and clinical retrospective radiomics study reveal causal relationships between brain imaging-derived phenotypes and epilepsy risk.

Brain imaging and behavior - 6 Apr 2026

Wu Huanhua, Ou Chulan, Yang Yuelong, Zhou Caihong, Cao Xiaozheng, Tan Yao

Abstract excerpt

This study investigates the causal relationships between brain imaging-derived phenotypes (IDPs) and epilepsy risk by integrating Mendelian randomization (MR) analysis and radiomics-based validation using brain magnetic resonance imaging (MRI) data. Two-sample MR analysis, leveraging genome-wide association study (GWAS) data, revealed that higher fractional anisotropy (FA) in the right posterior thalamic...

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PMID: 41942808
DOI: 10.1007/s11682-026-01145-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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