Article
The genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders.
Translational psychiatry - 26 May 2023
Ou Ya-Nan, Ge Yi-Jun, Wu Bang-Sheng, Zhang Yi, Jiang Yu-Chao, Kuo Kevin, Yang Liu, Tan Lan, Feng Jian-Feng, Cheng Wei, Yu Jin-Tai
Abstract excerpt
The fornix is a white matter bundle located in the center of the hippocampaldiencephalic limbic circuit that controls memory and executive functions, yet its genetic architectures and involvement in brain disorders remain largely unknown. We carried out a genome-wide association analysis of 30,832 UK Biobank individuals of the six fornix diffusion magnetic resonance imaging (dMRI) traits. The post-GWAS analysis...
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