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Article

Multimodal Impact of Number of Metastases and Genetic Alterations on Survival in Metastatic Non-Small Cell Lung Cancer.

JCO precision oncology - 1 May 2026

Wijetunga N Ari, Mankuzhy Nikhil P, Lebow Emily S, Boe Lillian A, Pike Luke R G, Schoenfeld Adam J, Shaverdian Narek, Chaunzwa Tafadzwa L, Jones David R, Chaft Jamie E, Rudin Charles M, Kris Mark G, Yu Helena A, Chang Jason C, Iyengar Puneeth, Gomez Daniel R

Abstract excerpt

PURPOSE: Oligometastatic disease (OMD) is an intermediate state of metastatic disease in which metastasis-directed therapy (MDT) may improve outcomes. The classification of OMD is inconsistent, typically defined by number of metastases without considering tumor biologic characteristics. To help optimize patient selection for MDT, we analyzed integrated genomic sequencing results from patients with metastatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42133899
DOI: 10.1200/PO-25-00597
PMCID: PMC13182819

Genes

OMD
ALK
EGFR
IMPACT
KMT2D
TBX3
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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