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Article

Next-Generation Sequencing: A Novel Approach to Distinguish Multifocal Primary Lung Adenocarcinomas from Intrapulmonary Metastases.

The Journal of molecular diagnostics : JMD - 1 Nov 2017

Patel Snehal B, Kadi Wendy, Walts Ann E, Marchevsky Alberto M, Pao Andy, Aguiluz Angela, Mudalige Tudor, Liu Zhenqui, Deng Nan, Lopategui Jean

Abstract excerpt

Distinguishing between multiple lung primary tumors and intrapulmonary metastases is imperative for accurate staging. The American Joint Committee on Cancer (AJCC) criteria are routinely used for this purpose but can yield equivocal conclusions. This study evaluated whether next-generation sequencing (NGS) using the 50-gene AmpliSeq Cancer Hotspot Panel version 2 can help facilitate this distinction. NGS was...

Read the complete abstract on PubMed

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diagnosis, Differential

Share to Neoplasm Metastasis

Share to Neoplasm Proteins

Share to Neoplasms, Multiple Primary

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 28866070
DOI: 10.1016/j.jmoldx.2017.07.006

Genes

BRAF
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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