From Familial Clustering to a Dedicated Classification: The Historical Recognition of Hereditary Tumor Syndromes in the WHO Classification of Tumors.

Abstract excerpt

BACKGROUND: Familial cancer aggregation has been recognized for more than 150 years. For much of that period, hereditary tumor predisposition was incorporated into tumor classification in a fragmented, organ-specific manner. Across successive editions, the WHO classification of tumours moved from morphology-based histologic typing toward an integrated classification that includes molecular pathology, inherited...

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