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Article

ROS-Responsive Trifluoperazine Prodrug Nanoparticles and Mesenchymal Stem Cell Exosomes Synergistically Modulate Astrocyte Phenotype for Spinal Cord Injury Repair.

ACS applied materials & interfaces - 27 May 2026

Cheng Yajun, Wang Rui, Bai Zhihui, Han Lin, Zhu Xiaodong, Li Ming, Liu Zhongtang

Abstract excerpt

Spinal cord injury (SCI) often triggers pronounced astrocytic edema, which worsens neurological deficits. To counteract the key role of Aquaporin-4 (AQP4) delocalization in this process, we developed a reactive oxygen species (ROS)-responsive nanodrug delivery system to restore AQP4 polarity and reduce edema. We synthesized a trifluoperazine (TFP) prodrug linked by a ROS-cleavable thioketal bond that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42131986
DOI: 10.1021/acsami.6c09304
PMCID: PMC13220221

Genes

AQP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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