Article

A free energy landscape screen reveals the disordered conformational ensemble of tropoelastin

2026-02-05

Abstract excerpt

Understanding how proteins explore their conformational energy landscapes is essential for linking sequence to function, yet current ensemble methods are limited by sampling inefficiency and poor scalability to large disordered systems. Here we introduce a free energy landscape screen (FELS), a conceptually different approach that replaces sampling-centric ensemble fitting with broad exploration of energy landscap...

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Literature Corpus work: 88db17f0-22bc-52e5-ae75-e5a936a92079
DOI: 10.64898/2026.02.03.703507

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