CTNNB1-Mutant High-Grade Endometrial Carcinoma: Clinical Outcome and Prevalence of Pilomatrix-Like and Corded Hyalinized Morphologies in an Institutional Case-Control Series.

Abstract excerpt

The occurrence of somatic CTNNB1 pathogenic mutations has been recently recognized in high-grade endometrial carcinoma (HG-EMC) in association with pilomatrix-like (PM-L) morphology and an aggressive clinical course, highlighting the need for further study on the biologic and clinical importance of CTNNB1 alterations in HG-EMC. Thus, we document the clinical and pathologic characteristics of an institutional...

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