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Article

Adnexal Endometrioid Carcinomas With Sex Cord-Like Morphology are Frequently PAX8-Negative, SOX17-Positive, and Enriched for CTNNB1 Alterations.

The American journal of surgical pathology - 1 Jun 2026

Lengyel Krisztina, Musick Alexis, Fisch Adam S, Lin Lawrence Hsu, Turashvili Gulisa, Young Robert H, Oliva Esther, Devins Kyle M

Abstract excerpt

Sex cord-like morphology is now a well-known feature of occasional examples of endometrioid carcinoma of the ovary or fallopian tube. Recently, we have observed that these tumors are frequently negative for PAX8, prompting us to review their morphologic, immunohistochemical, and genomic spectrum. Twenty tumors (17 ovarian, 3 fallopian tube) with available tissue were identified in patients ranging from 32 to 78...

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Identifiers

PMID: 41808247
DOI: 10.1097/PAS.0000000000002537

Genes

PAX8
CTNNB1
SOX17
POLE
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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