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Article

Optimized interpretation of p53 immunohistochemistry for prediction of TP53 mutations and patient survival in DLBCL.

Clinical and experimental medicine - 13 May 2026

Ruan Jing, Wang Yupeng, Jia Congwei, Zhou Daobin, Zhang Yan, Zhao Danqing, Chen Xinyuan, Wei Chong, Zhang Wei

Abstract excerpt

The prognostic value of p53 immunohistochemical (IHC) staining in diffuse large B cell lymphoma (DLBCL) remains controversial. We retrospectively included 149 patients who were diagnosed with and treated for DLBCL at Peking Union Medical College Hospital (PUMCH). TP53 IHC staining and TP53 sequencing was performed from paraffin-embedded biopsy tissues. Clinical information including basic characteristics and...

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Identifiers

PMID: 42126463
DOI: 10.1007/s10238-026-02174-8
PMCID: PMC13341874

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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