Prognostic impact of TP53 mutation in newly diagnosed diffuse large B-cell lymphoma patients treated in the FIL-DLCL04 trial.

doi:10.1111/bjh.17971

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Article

Prognostic impact of TP53 mutation in newly diagnosed diffuse large B-cell lymphoma patients treated in the FIL-DLCL04 trial.

British journal of haematology - 1 Mar 2022

Chiappella Annalisa, Diop Fary, Agostinelli Claudio, Novo Mattia, Nassi Luca, Evangelista Andrea, Ciccone Giovannino, Di Rocco Alice, Martelli Maurizio, Melle Federica, Moia Riccardo, Motta Giovanna, Righi Simona, Santambrogio Elisa, Tucci Alessandra, Balzarotti Monica, Ladetto Marco, Pileri Stefano A, Gaidano Gianluca, Vitolo Umberto

Abstract excerpt

The prognostic role of TP53 disruption has been established in diffuse large B-cell lymphoma (DLBCL). Aim of this analysis was to correlate TP53 mutations by Sanger sequencing, cell of origin (COO) profile by Lymph2Cx panel on the NanoString platform and MYC, BCL2 and BCL6 overexpression or re-arrangements by immunohistochemistry (IHC) and fluorescent in-situ hybridization (FISH), with outcome in DLBCL patients...

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PMID: 34951009
DOI: 10.1111/bjh.17971

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