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Article

Identify truly high-risk TP53-mutated diffuse large B cell lymphoma patients and explore the underlying biological mechanisms.

Cell communication and signaling : CCS - 15 Aug 2024

Du Kai-Xin, Wu Yi-Fan, Hua Wei, Duan Zi-Wen, Gao Rui, Liang Jun-Heng, Li Yue, Yin Hua, Wu Jia-Zhu, Shen Hao-Rui, Wang Li, Shao Yang, Li Jian-Yong, Liang Jin-Hua, Xu Wei

Abstract excerpt

TP53 mutation (TP53-mut) correlates with inferior survival in many cancers, whereas its prognostic role in diffuse large B-cell lymphoma (DLBCL) is still in controversy. Therefore, more precise risk stratification needs to be further explored for TP53-mut DLBCL patients. A set of 2637 DLBCL cases from multiple cohorts, was enrolled in our analysis. Among the 2637 DLBCL patients, 14.0% patients (370/2637) had...

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Share to TP53 gene
Share to Lymphoma, Large B-Cell, Diffuse

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mutation, Missense

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 39148095
DOI: 10.1186/s12964-024-01765-w
PMCID: PMC11325619

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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