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Article

Prognostic impact of TP53 mutations in diffuse large B-cell lymphoma.

Annals of hematology - 10 Feb 2026

Yu Jiayi, He Qiang, Yan Yuting, Liu Kuntong, Xie Rong, Ma Ji, Wang Liang

Abstract excerpt

To evaluate the prognostic value of TP53 mutations in patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively analyzed the clinical data and gene sequencing results of 253 newly diagnosed DLBCL. Survival and correlation analyses were performed. We further revealed significant prognostic heterogeneity among different TP53 hotspot mutations, with mutations at codons G245, R175, R273, and R282...

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Source

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Identifiers

PMID: 41665720
DOI: 10.1007/s00277-026-06882-9
PMCID: PMC12891153

Genes

TP53

Provenance

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