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Article

Cox-MK: a model-X knockoff framework for genome-wide survival association analysis.

Genetics - 6 Jul 2026

Hu Lin, Yang Chen, Tang Zihuan, Yan Jingmin, Cheng Huaying, Bao Lei, Ji Jiadong, Ma Shiyang, Zhang Tao

Abstract excerpt

In genome-wide survival association studies, time-to-event (TTE) phenotypes are often underutilized due to the challenges of large-scale multiple testing under linkage disequilibrium and heavy censoring. We propose Cox-MK, a novel genome-wide survival analysis framework that integrates knockoff statistics with the saddlepoint approximation (SPA), enabling SNP-level false discovery rate (FDR) control in...

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Identifiers

PMID: 42126072
DOI: 10.1093/genetics/iyag123

Genes

CD247
EDNRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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