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Article

Power and sample size calculations for SNP association studies with censored time-to-event outcomes.

Genetic epidemiology - 1 Sept 2012

Owzar Kouros, Li Zhiguo, Cox Nancy, Jung Sin-Ho

Abstract excerpt

For many clinical studies in cancer, germline DNA is prospectively collected for the purpose of discovering or validating single-nucleotide polymorphisms (SNPs) associated with clinical outcomes. The primary clinical endpoint for many of these studies are time-to-event outcomes such as time of death or disease progression which are subject to censoring mechanisms. The Cox score test can be readily employed to...

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PMID: 22685040
DOI: 10.1002/gepi.21645
PMCID: PMC3592339

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