Article
The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
The Journal of biological chemistry - 4 Sept 2009
Saegusa Jun, Yamaji Satoshi, Ieguchi Katsuaki, Wu Chun-Yi, Lam Kit S, Liu Fu-Tong, Takada Yoko K, Takada Yoshikazu
Abstract excerpt
It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling. We found that expression of alphavbeta3 enhanced IGF-1-induced proliferation of Chinese hamster ovary cells in serum-free conditions (in the absence of vitronectin). We hypothesized that the direct integrin binding to IGF-1...
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