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Article

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.

The Journal of biological chemistry - 27 Jun 2008

Mori Seiji, Wu Chun-Yi, Yamaji Satoshi, Saegusa Jun, Shi Biao, Ma Zi, Kuwabara Yasuko, Lam Kit S, Isseroff R Rivkah, Takada Yoko K, Takada Yoshikazu

Abstract excerpt

Integrins play a role in fibroblast growth factor (FGF) signaling through cross-talk with FGF receptors (FGFRs), but the mechanism underlying the cross-talk is unknown. We discovered that FGF1 directly bound to soluble and cell-surface integrin alphavbeta3 (K(D) about 1 microm). Antagonists to alphavbeta3 (monoclonal antibody 7E3 and cyclic RGDfV) blocked this interaction. alphavbeta3 was the predominant, if not...

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Source

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Identifiers

PMID: 18441324
DOI: 10.1074/jbc.M801213200
PMCID: PMC2440593

Genes

FGF1
FGFR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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