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Article

Investigation of the Effects of Cadherin 23 and Oncomodulin on Early Progressive Hearing Loss Using a New Oncomodulin Mouse Model.

International journal of molecular sciences - 25 Apr 2026

Kim Mi-Jung, Fuentes Robert J, Zhou Yingjie, Zheng Jing

Abstract excerpt

Oncomodulin (OCM) is the most abundant Ca2+ buffering protein found in mature outer hair cells (OHCs). Cadherin 23 (CDH23) is a crucial component of the tip-links in hair cell stereocilia. The absence or dysfunction of these two proteins contributes to the early onset of age-related hearing loss (AHL). In this study, we investigated the effects of the Cdh23753G→A mutation on OHC function using new Ocm-knockout...

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Source

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Identifiers

PMID: 42123419
DOI: 10.3390/ijms27093835
PMCID: PMC13163798

Genes

OCM
CDH23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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