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Article

Two new mouse alleles of Ocm and Slc26a5.

Hearing research - 1 Oct 2024

Lachgar-Ruiz Marìa, Ingham Neil J, Martelletti Elisa, Chen Jing, James Elysia, Panganiban Clarisse, Lewis Morag A, Steel Karen P

Abstract excerpt

The genes Ocm (encoding oncomodulin) and Slc26a5 (encoding prestin) are expressed strongly in outer hair cells and both are involved in deafness in mice. However, it is not clear if they influence the expression of each other. In this study, we characterise the auditory phenotype resulting from two new mouse alleles, Ocmtm1e and Slc26a5tm1Cre. Each mutation leads to absence of detectable mRNA transcribed from the...

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PMID: 39241555
DOI: 10.1016/j.heares.2024.109109

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