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Article

Decoding IGLL5 Mutation-Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2026

Zhao Andi, Wei Haoyu, Zhou Chenyu, Sun Xinping, Da Shuyan, Liu Haiyu, Wang Zijin, Zhu Hui, Shen Shiya, Shao Qing, Gong Qi, Liu Hu, Chen Xuejuan

Abstract excerpt

Ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) is driven by both genetic and immune microenvironmental factors, yet its pathogenic mechanisms remain incompletely understood. We previously identified IGLL5 as a recurrently mutated gene associated with poor prognosis in OAML. Functional and mechanistic analyses focusing on the S47G and A54G mutants show that these variants enhance association with...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to CXCL10 gene

Share to Lymphoma, B-Cell, Marginal Zone

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Source

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Identifiers

PMID: 42118140
DOI: 10.1002/advs.202518780
PMCID: PMC13335846

Genes

IGLL5
BCR
BTK
CD79A
CD79B
CXCL10
CXCL11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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