Article
Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.
Oncotarget - 20 Sept 2016
Johansson Patricia, Klein-Hitpass Ludger, Grabellus Florian, Arnold Georg, Klapper Wolfram, Pförtner Roman, Dührsen Ulrich, Eckstein Anja, Dürig Jan, Küppers Ralf
Abstract excerpt
The pathogenesis of ocular adnexal marginal zone lymphomas of mucosa-associated lymphatic tissue-type (OAML) is still poorly understood. We analyzed 63 cases of such lymphomas for non-synonymous mutations in 24 candidate genes by amplicon sequencing. We validated frequent mutations in the NF-κB regulators MYD88, TNFAIP3 and TNIP1 in OAML, but also identified recurrent mutations in several additional components of...
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