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Article

Recurrent MSC E116K mutations in ALK-negative anaplastic large cell lymphoma.

Blood - 27 Jun 2019

Luchtel Rebecca A, Zimmermann Michael T, Hu Guangzhen, Dasari Surendra, Jiang Manli, Oishi Naoki, Jacobs Hailey K, Zeng Yu, Hundal Tanya, Rech Karen L, Ketterling Rhett P, Lee Jeong-Heon, Eckloff Bruce W, Yan Huihuang, Gaonkar Krutika S, Tian Shulan, Ye Zhenqing, Kadin Marshall E, Sidhu Jagmohan, Jiang Liuyan, Voss Jesse, Link Brian K, Syrbu Sergei I, Facchetti Fabio, Bennani N Nora, Slager Susan L, Ordog Tamas, Kocher Jean-Pierre, Cerhan James R, Ansell Stephen M, Feldman Andrew L

Abstract excerpt

Anaplastic large cell lymphomas (ALCLs) represent a relatively common group of T-cell non-Hodgkin lymphomas (T-NHLs) that are unified by similar pathologic features but demonstrate marked genetic heterogeneity. ALCLs are broadly classified as being anaplastic lymphoma kinase (ALK)+ or ALK-, based on the presence or absence of ALK rearrangements. Exome sequencing of 62 T-NHLs identified a previously unreported...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31101622
DOI: 10.1182/blood.2019000626
PMCID: PMC6598380

Genes

ALK
MSC
MYC
E2F2
DUSP22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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