Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Fusion Gene Transcripts and Targetable Mutations in High-Risk B-ALL With Exceptional Response to Venetoclax-Based Therapy.

Genes, chromosomes & cancer - 1 May 2026

Tu Jifang, Wang Huanping, Wang Yungui, Zhou Junhao, Gao Xiangli, Lou Yinjun, Tong Hongyan

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is a genetically heterogeneous malignancy characterized by a broad spectrum of chromosomal and gene abnormalities that define distinct genetic subtypes driving disease development. Although numerous driver fusion genes have been documented, a considerable proportion of ALL cases remain inadequately defined, classified, and consequently lack access to precisely targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BCL6 gene

Share to CREBBP gene

Share to Mutation

Share to Oncogene Proteins, Fusion

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Sulfonamides

Source

Identifiers

PMID: 42117742
DOI: 10.1002/gcc.70134

Genes

BCL2
BCL6
ARID1B
CREBBP
GRIK2
IGL
MAN1A1
OSTM1
ZBTB24
ZCCHC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Fusion Gene Transcripts and Targetable Mutations in High-Risk B-ALL With Exceptional Response to Venetoclax-Based Therapy.PMID 42117742Read ↗

Advances in the diagnosis and classification of B-ALL: comparative insights from updated guidelines.Semantic proximity Read ↗

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemiaSemantic proximity Read ↗

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.Semantic proximity Read ↗

Identification of Novel Fusion Genes in Pediatric B-ALL patients Using Whole Transcriptome SequencingSemantic proximity Read ↗

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Molecular characterization and biomarker identification in paediatric B-cell acute lymphoblastic leukaemia.Semantic proximity Read ↗

Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Identification of Novel Fusion Genes in Pediatric B-ALL patients Using Whole Transcriptome SequencingSemantic proximity Read ↗

Molecular Characterization of Pediatric B-cell Acute Lymphoblastic Leukemia using Integrative Transcriptomics: A Multicenter Study in ArgentinaSemantic proximity Read ↗

How to Combine Multiple Tools for the Genetic Diagnosis Work-up of B-Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcomeSemantic proximity Read ↗

IKZF1plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.