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Advances in the diagnosis and classification of B-ALL: comparative insights from updated guidelines.

Blood advances - 26 May 2026

Chen Xue, Yuan Lili, Ma Xiaoli, Wang Fang, Zhang Yang, Fang Jiancheng, Cao Panxiang, Wang Tong, Chen Jiaqi, Zhou Xiaosu, Long Jing, Liu Hongxing

Abstract excerpt

ABSTRACT: Accurate molecular classification is essential for diagnosis, risk stratification, and treatment selection in B-cell lymphoblastic leukemia (B-ALL). In this study, we performed a comprehensive, real-world reclassification of 1015 consecutively diagnosed B-ALL patients using the fifth edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO-HAEM5) and the International...

Topics

Humans
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Male
Female
Adult
Middle Aged
Prognosis
Adolescent
Practice Guidelines as Topic
Child
Young Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Gene Expression Profiling

Mutation

Child, Preschool

Source

Open in PubMed Open full text

Identifiers

PMID: 41886641
DOI: 10.1182/bloodadvances.2025017301
PMCID: PMC13207558

Genes

ABL1
BCR
ETV6
HLF
IDH1
RUNX1
ZEB2
ZNF384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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