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Article

A novel insight into the risk of depression and anxiety onset in Parkinson's disease: the implications of GBA1 and LRRK2.

Parkinsonism & related disorders - 1 Jul 2026

Yang Dehao, Wang Junchao, Huang Honghao, Lin Shenyi, Liu Zijia, Zhang Shishu, Xu Jingxuan, Zhang Bo, Cai Hejia, Lin Hai, Huang Suwen, Chen Guangyong

Abstract excerpt

BACKGROUND: The non-motor symptoms of Parkinson's disease (PD) conspicuously undermine the quality of life of patients, with mood disorders being the most prevalent. However, reliable indicators for early prediction are currently scarce. Glucocerebrosidase beta 1 (GBA1) and leucine-rich repeat kinase 2 (LRRK2) mutations are regarded as associated with depression and anxiety. Nevertheless, relevant longitudinal...

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Source

Identifiers

PMID: 42114177
DOI: 10.1016/j.parkreldis.2026.108341

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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