Article
Clinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease.
Journal of the neurological sciences - 15 Oct 2017
da Silva Camilla P, de M Abreu Gabriella, Cabello Acero Pedro H, Campos Mário, Pereira João S, de A Ramos Sarah R, Nascimento Caroline M, Voigt Danielle D, Rosso Ana Lucia, Araujo Leite Marco A, Vasconcellos Luiz Felipe R, Nicaretta Denise H, Della Coletta Marcus V, da Silva Delson José, Gonçalves Andressa P, Dos Santos Jussara M, Calassara Veluma, Valença Débora Cristina T, de M Martins Cyro J, Santos-Rebouças Cíntia B, Pimentel Márcia M G
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder characterized by remarkable phenotypic variability. Accumulated evidence points that the manifestation of PD clinical signs might be differentially modified by genetic factors, as mutations in LRRK2 and GBA genes. In this sense, the clarification of the genotype-phenotype correlations in PD has important implications in predicting prognosis and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.