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Article

On Efficient and Accurate Calculation of Significance P-Values for Sequence Kernel Association Testing of Variant Set.

Annals of human genetics - 1 Mar 2016

Wu Baolin, Guan Weihua, Pankow James S

Abstract excerpt

The objective of this paper is to discuss and develop alternative computational methods to accurately and efficiently calculate significance P-values for the commonly used sequence kernel association test (SKAT) and adaptive sum of SKAT and burden test (SKAT-O) for variant set association. We show that the existing software can lead to either conservative or inflated type I errors. We develop alternative and...

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Identifiers

PMID: 26757198
DOI: 10.1111/ahg.12144
PMCID: PMC4761292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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